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KMID : 1123920090230010150
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 1 p.150 ~ p.157
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Effect of Bupleuri Radix on Inflammatory Cytokine Secretion to HMC and Mouse Immmune Cells
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Sung Woo Choi
Kang Hee
Shim Bum-Sang
Kim Sung-Hoon
Choi Seung-Hoon
Ahn Kyoo-Suk
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Abstract
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This research was performed in order to investigate the anti-inflammatory effects of Bupleuri Radix(BR) on the Immune response in vitro. Cellular proliferation and cytokine production were measured in mast cells or mouse B cells or CD4 Th cells. BR water extract inhibited the secretions of TNF- and IL-6 in PMA/A23187 stimulated HMC-1 cells. It increased proliferation but did not affect the expressions of CD69 or CD23 in rIL-4/anti-CD40 activated S cells. BR reduced surface IgE expression and secreted IgE but increased the production of IL-4, IFN- and IgG1 in the same cells. BR caused an increase in proliferation in anti-CD3/anti-CD28 stimulated CD4 Th cells but it did not affect the differentiation of Th1 or Th2 cells. However, IL-2 was increased in BR treated Th2 cells. Considering the above-mentioned results, BR can be applied to a broad range of anti-inflammatory reactions, but our data suggest that it will not be likely to exert any effects on type 1 allergic response.
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KEYWORD
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Bupleuri Radix(BR), HMC-1, B cells, T cells, cytokine, inflammation
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